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Exploring,,mechanisms,,of,,this,,interaction,,and,,potential,,toxicity,,for,,certain,,drugs.,,Sim,SC,,Ingelman-Sundberg,M.,Geriatrics.,Additionally,,,,food,,,interactions,,,,as,,,well,,,as,,,elimination,,,half-life,,,(EHL),,,times,,,and,,,Q0,,,values,,,are,,,displayed.,,,(A),,Composition,,of,,a,,drug-cocktail.,,

There,,,were,,,three,,,reasons,,,for,,,the,,,low,,,metabolism,,,rate:,,,CYP-polymorphism:,,,the,,,child,,,was,,,found,,,to,,,be,,,a,,,CYP2D6,,,poor,,,metabolizer,inhibition,,,of,,,CYP3A4,,,by,,,clarithromycin,,,andinhibition,,,of,,,UGT,,,by,,,valproic,,,acid.,,,A,knowledge,base,of,xenobiotic,metabolism,and,the,effect,of,polymorphisms,could,prevent,ADR,and,cases,of,death.Xenobiotic,metabolism,and,detoxification,(especially,for,drugs),are,separated,into,three,different,phases,of,reaction.,The,,,activation,,,of,,,prodrugs,,,by,,,CYPs,,,might,,,be,,,a,,,better,,,approach,,,(21).Not,,,only,,,can,,,drugs,,,participate,,,in,,,the,,,alteration,,,of,,,drug,,,metabolism,,,but,,,food,,,and,,,herbs,,,also,,,have,,,a,,,proven,,,influence;,,,e.g.,,,Future,Med.,Kell,,,DB,,,,Dobson,,,PD,,,,Bilsland,,,E,,,,Oliver,,,SG.,,,To,,allow,,chemical,,functionality,,,such,,as,,handling,,chemical,,data,,within,,MySQL,,,the,,MyChem,,package,,was,,included.Information,,about,,∼3000,,CYP,,drug,,interactions,,and,,2000,,polymorphisms,,were,,extracted,,from,,the,,SuperCYP,,database,,(27).,,Drug,Healthc.,An,example,of,a,PubMed,reference,is,shown.,Genomics.,

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